Effective postoperative acute pain control can reduce complications such as pneumonia, deep vein thrombosis, infection, chronic pain and depression[3]
Adequate postoperative acute pain control can effectively prevent the development of chronic pain[4]
Patients’ quality of life can be greatly improved by the management of acute postoperative pain[5]
The most consistent feature associated with the occurrence of CPSP is the duration of the severe acute postoperative pain. Acute pain leads to central sensitization, reduces the mechanical threshold and exaggerates the response to noxious stimuli, which causes an intensification of acute pain and long-term postoperative pain[6].
Note: Chronic post-surgical pain (CPSP): pain develops after surgical intervention and lasts at least 2 months
Cautious and thoughtful perioperative pain planning is necessary as preoperative pain, additional painful noxious intraoperative inputs such as retraction and postoperative inflammatory processes can all cause acute pain and CPSP[7].
Naldebain can be used in combination with either morphine or NSAID for management of moderate to severe postoperative pain and inhibition of CPSP development.
For the graph shown below, the blue dotted line represents Naldebain + Multimodal Analgesic (MMA); it provides preventive analgesia and global perioperative pain processing coverage, which shows excellent intraoperative and postoperative analgesic efficacy (pain intensity < 3), and thus reduces the CPSP[4].
